Marvel 1602, by Neil Gaiman
Well-written, and a fun spin on the whole Jack Kirby/Stan Lee character empire. Mutants are called Witchbreed, and are hunted by the Inquisition.
Strangely, the character I'm most into is Daredevil, all-too brooding and self-absorbed in his usual incarnation; here a blind minstrel with a penchant for one-liners.
A fun read, I must say, especially necessary for me right now, since most of the time these days I'm knee-deep in non-fiction Latin American history or fighting through intense Shakespearean analyses.
Oh, and did I mention the bitchin' scratchboard covers by Scott McKowen? They're, well, bitchin'.